Antibody-drug conjugates as drug carrier systems for bioactive agents. Issue 1 (2nd January 2016)

• Record Type: Journal Article
• Authors: Akash, Muhammad Sajid Hamid; Rehman, Kanwal; Parveen, Amna; Ibrahim, Muhammad
• Is Part Of: International journal of polymeric materials. Volume 65:Issue 1(2016)
• Page Start: 1
• Page End: 10
• Publication Date: 2016-01-02
• Subjects: Antibody-drug conjugates -- drug release strategies from ADC -- key requirements for ADC -- linkers -- monoclonal antibodies -- pharmacokinetic and pharmacodynamic properties of ADC; Polymers -- Periodicals; Plastics -- Periodicals; 620.19205
• DOI: 10.1080/00914037.2015.1038818
• Languages: English
• ISSNs: 0091-4037

Abstract

ABSTRACT: Conventional therapeutic strategies for the treatment of various types of cancers and tumors are known to have poor therapeutic indexes, lack of specificity, and potential cytotoxic effects on normal healthy tissues. Antibody-drug conjugates (ADCs) are considered as novel therapeutic strategy for the treatment of various diseases especially cancer. ADCs reduce the chances of systemic cytotoxicity and, ultimately, increase the therapeutic index of conjugated drug. ADCs are stable in systemic circulation, but for the success of ADCs, all the components of ADC should function in a flawless manner. Despite of these components of ADCs, target selection is another stringent factor that also needs equal consideration during the development of ADC. The authors briefly discuss the key requirements of ADCs that seek further advancements for the success of ADCs. GRAPHICAL ABSTRACT: