One‐Pot Synthesis of Some Dynamic 2‐Substituted Benzoxazinones and Their Corresponding Qinazolinones of Anticipated Biological Activity. (9th January 2015)

• Record Type: Journal Article
• Authors: El‐Hashash, Maher A.; Azab, Mohamed E.; Morsy, Jehan M.
• Is Part Of: Journal of heterocyclic chemistry. Volume 53:Number 1(2016:Jan.)
• Page Start: 95
• Page End: 101
• Publication Date: 2015-01-09
• Subjects: Benzoxazinone -- quinazolinone -- quinoline -- Mannich reaction; Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2389
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Reactions of 6‐bromo‐2‐isopropyl‐4(3H)‐3, 1‐benzoxazin‐4‐one toward mono‐ and di‐dentate nitrogen nucleophiles, e.g. primary aliphatic andaromatic amines, 1, 2‐phenylenediamine, hydrazine hydrate, and formamide, have been investigated and afford the corresponding quinazolinones which are expected to have some interestingbiological activity . The behavior of 3, 1‐benzoxazin‐4‐one toward active methylene compounds, namely, acetylacetone in basic medium has been studied and gave 3‐acetylquinoline. The last reaction is considered as an illustrative model of heterocyclic transformation reactions. Abstract :