Cobalt‐Catalyzed Electrophilic Cyanation of Arylzinc Halides with N‐Cyano‐N‐phenyl‐p‐methylbenzenesulfonamide (NCTS). Issue 16 (13th August 2015)

• Record Type: Journal Article
• Authors: Cai, Yingxiao; Qian, Xin; Rérat, Alice; Auffrant, Audrey; Gosmini, Corinne
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 16/17(2015)
• Page Start: 3419
• Page End: 3423
• Publication Date: 2015-08-13
• Subjects: benzonitriles -- cobalt -- cross‐coupling -- electrophilic cyanation -- organozinc compounds; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500245
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The cobalt‐catalyzed cross‐coupling of organozinc bromides with N ‐cyano‐ N ‐phenyl‐ p ‐methylbenzenesulfonamide (NCTS) is described. The same cobalt catalyst, cobalt(II) bromide, was used for both the synthesis of the organozinc species and the cross‐coupling reaction. However in this case, a catalytic amount of zinc dust is necessary in the second step to release the low‐valent cobalt. Under these mild conditions, moderate to excellent yields of different benzonitriles were obtained. Abstract :