A Catalytic Approach to Quinoline Fused Lactones and Lactams from Glycine Derivatives. Issue 16 (18th November 2015)

• Record Type: Journal Article
• Authors: Huo, Congde; Yuan, Yong; Chen, Fengjuan; Wang, Yajun
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 16/17(2015)
• Page Start: 3648
• Page End: 3654
• Publication Date: 2015-11-18
• Subjects: aerobic conditions -- annulation -- glycine derivatives -- quinoline fused lactams -- quinoline fused lactones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500513
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A dual catalyst system [copper(II) chloride‐sulfuric acid, (CuCl2 ‐H2 SO4 )]‐promoted aerobic oxidative reaction of glycine derivatives with 2, 3‐dihydrofurans or 2, 3‐dihydropyrroles has been explored, affording an efficient synthesis of high value quinoline fused lactones and lactams. The application of this new methodology to the synthesis of a bioactive C ring extension analogue of luotonin A has been accomplished in a concise three‐step sequence. Abstract :