Antibacterial poly(ethylene glycol) hydrogels from combined epoxy‐amine and thiol‐ene click reaction. Issue 5 (16th September 2015)

• Record Type: Journal Article
• Authors: Zhou, Chao; Truong, Vinh X.; Qu, Yue; Lithgow, Trevor; Fu, Guodong; Forsythe, John S.
• Is Part Of: Journal of polymer science. Volume 54:Issue 5(2016)
• Page Start: 656
• Page End: 667
• Publication Date: 2015-09-16
• Subjects: antibacterial hydrogel -- epoxy‐amine ring opening reaction -- quaternary ammonium -- thiol‐ene click chemistry; 547
• DOI: 10.1002/pola.27886
• Languages: English
• ISSNs: 0887-624X

Abstract

ABSTRACT: Antibacterial hydrogels containing quaternary ammonium (QA) groups were prepared via a facile thiol‐ene "click" reaction using multifunctional poly(ethylene glycol) (PEG). The multifunctional PEG polymers were prepared by an epoxy‐amine ring opening reaction. The chemical and physical properties of the hydrogels could be tuned with different crosslinking structures and crosslinking densities. The antibacterial hydrogel structures prepared from PEG Pendant QA were less well‐defined than those from PEG Chain‐End QA. Furthermore, functionalization of the PEG‐type hydrogels with QA groups produced strong antibacterial abilities against Staphylococcus aureus, and therefore has the potential to be used as an anti‐infective material for biomedical devices. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem.2016, 54, 656–667 Abstract : Antibacterial PEG hydrogels prepared from an epoxy‐amine ring opening reaction and thiol‐ene click chemistry containing quaternary ammonium groups effectively inhibited S. aureus bacteria growth and biofilm formation.