Electrocatalytic Generation of Amidyl Radicals for Olefin Hydroamidation: Use of Solvent Effects to Enable Anilide Oxidation. (6th January 2016)

• Record Type: Journal Article
• Authors: Zhu, Lin; Xiong, Peng; Mao, Zhong‐Yi; Wang, Yong‐Heng; Yan, Xiaomei; Lu, Xin; Xu, Hai‐Chao
• Is Part Of: Angewandte Chemie. Volume 128:Number 6(2016)
• Page Start: 2266
• Page End: 2269
• Publication Date: 2016-01-06
• Subjects: Amidylradikale -- Elektrochemie -- Ferrocen -- Hydroamidierung -- Redoxkatalyser; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201510418
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Oxidative generation of synthetically important amidyl radicals from N−H amides is an appealing and yet challenging task. Previous methods require a stoichiometric amount of a strong oxidant and/or a costly noble‐metal catalyst. We report herein the first electrocatalytic method that employs ferrocene (Fc), a cheap organometallic reagent, as the redox catalyst to produce amidyl radicals from N ‐aryl amides. Based on this radical‐generating method, an efficient intramolecular olefin hydroamidation reaction has been developed.