Expedient Synthesis of (+)‐Lycopalhine A. (8th January 2016)
- Record Type:
- Journal Article
- Title:
- Expedient Synthesis of (+)‐Lycopalhine A. (8th January 2016)
- Main Title:
- Expedient Synthesis of (+)‐Lycopalhine A
- Authors:
- Williams, Benjamin M.
Trauner, Dirk - Abstract:
- Abstract: Two amino acids play a key role in the first total synthesis of lycopalhine A.l ‐glutamic acid serves as a convenient chiral starting material for the 13‐step synthesis, andl ‐proline promotes an unusual 5‐ endo ‐trig Mannich cyclization that generates the central pyrrolidine ring of the Lycopodium alkaloid. The bicyclo[3.3.0]octanol moiety of the molecule is formed through an intramolecular aldol addition that may occur spontaneously in nature.
- Is Part Of:
- Angewandte Chemie. Volume 128:Number 6(2016)
- Journal:
- Angewandte Chemie
- Issue:
- Volume 128:Number 6(2016)
- Issue Display:
- Volume 128, Issue 6 (2016)
- Year:
- 2016
- Volume:
- 128
- Issue:
- 6
- Issue Sort Value:
- 2016-0128-0006-0000
- Page Start:
- 2231
- Page End:
- 2234
- Publication Date:
- 2016-01-08
- Subjects:
- Aldolreaktionen -- Aminosäuren -- Lycopodium-Alkaloide -- Mannich-Reaktion -- Totalsynthesen
Chemistry -- Periodicals
540 - Journal URLs:
- http://onlinelibrary.wiley.com/ ↗
- DOI:
- 10.1002/ange.201509602 ↗
- Languages:
- English
- ISSNs:
- 0044-8249
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0902.000000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 30.xml