Catalytic Enantioselective Total Synthesis of Riccardiphenol B. Issue 3 (21st January 2016)

• Record Type: Journal Article
• Authors: Cottet, Pierre; Bleschke, Christian; Capdevila, Montse Guiteras; Tissot, Matthieu; Alexakis, Alexandre
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 3(2016)
• Page Start: 417
• Page End: 425
• Publication Date: 2016-01-21
• Subjects: asymmetric catalysis -- enolate trapping -- Michael addition -- quaternary stereocenters -- riccardiphenol B -- sesquiterpenes -- total synthesis; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500928
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The first catalytic enantioselective total synthesis of riccardiphenol B, a sesquiterpene derivative isolated from a Japanese collection of the liverwort Riccardia crassa, has been achieved. A copper‐catalyzed asymmetric conjugate addition of trimethylaluminum was used at an early stage to generate the quaternary stereogenic center with high enantiomeric excess. The corresponding sterically encumbered aluminum enolate was directly trapped with an α‐amino ether, allowing after oxidation, the release of a key intermediate in the total synthesis of the target natural product. Abstract :