Targeting plasma cells: are we any closer to a panacea for diseases of antibody‐secreting cells?. Issue 1 (March 2016)

• Record Type: Journal Article
• Authors: Low, Michael; Infantino, Simona; Grigoriadis, George; Tarlinton, David
• Is Part Of: Immunological reviews. Volume 270:Issue 1(2016)
• Page Start: 78
• Page End: 94
• Publication Date: 2016-03
• Subjects: antibody‐secreting cells -- plasma cells -- therapeutics; Immunology -- Periodicals; Transplantation of organs, tissues, etc -- Periodicals; 616.079
• DOI: 10.1111/imr.12388
• Languages: English
• ISSNs: 0105-2896

Abstract

Summary: Antibody‐secreting cells (ASCs) are critical for a functional and effective adaptive immune system. In a number of illnesses, however, these same cells contribute to the underlying disease state leading to significant morbidity and mortality. While therapeutic targeting of antibody‐secreting cells has progressed significantly over the last two decades, many of these conditions remain major health problems. In this review, we will discuss current and potential therapeutic targeting of ASCs in the context of the known biology of these cells.