Preparation of a New Chiral Stationary Phase Based on Macrocyclic Amide Chiral Selector for the Liquid Chromatographic Chiral Separations. Issue 3 (4th January 2016)

• Record Type: Journal Article
• Authors: Sung, Ji Yeong; Choi, Seung Hyuck; Hyun, Myung Ho
• Is Part Of: Chirality. Volume 28:Issue 3(2016)
• Page Start: 253
• Page End: 258
• Publication Date: 2016-01-04
• Subjects: chiral stationary phase -- enantiomer separation -- liquid chromatography -- macrocyclic amide chiral selector; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22569
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: A new chiral stationary phase (CSP) based on macrocyclic amide receptor was prepared starting from (1R, 2R)‐1, 2‐diphenylethylenediamine. The new CSP was successfully applied to the resolution of various N‐(substituted benzoyl)‐α‐amino amides with reasonably good separation factors and resolutions (α = 1.75 ~ 2.97 and RS = 2.89 ~ 6.82 for 16 analytes). The new CSP was also applied to the resolution of 3‐substituted 1, 4‐benzodiazepin‐2‐ones and some diuretic chiral drugs including bendroflumethiazide and methylchlothiazide and metolazone. The resolution results for 3‐substituted 1, 4‐benzodiazepin‐2‐ones and some diuretic chiral drugs were also reasonably good. Chirality 28:253–258, 2016 . © 2016 Wiley Periodicals, Inc. Abstract :