Occurrence of Enantioselectivity in Nature: The Case of (S)‐Norcoclaurine. Issue 3 (5th January 2016)

• Record Type: Journal Article
• Authors: Ghirga, Francesca; Quaglio, Deborah; Ghirga, Patrizio; Berardozzi, Simone; Zappia, Giovanni; Botta, Bruno; Mori, Mattia; D'Acquarica, Ilaria
• Is Part Of: Chirality. Volume 28:Issue 3(2016)
• Page Start: 169
• Page End: 180
• Publication Date: 2016-01-05
• Subjects: norcoclaurine -- enantioselective HPLC -- norcoclaurine synthase -- enantioselective synthesis -- chemoenzymatic synthesis; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22566
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: This review article is aimed at providing a monographic overview on (S)‐norcoclaurine (NC) alkaloid from three diverse points of view, collected all together for the first time: 1) the synthetic one, where the compound is seen as a target chiral molecule to be obtained in the highest optical purity and as a starting point for the development of biocatalyticasymmetric syntheses of tetrahydroisoquinoline alkaloids; 2) the chromatographic one, which addresses the HPLC separation of the two NC enantiomers; and 3) the biochemical one, for which a thorough understanding of the topology and mechanism of action of norcoclaurine synthase (NCS) enzyme is still a matter of debate. Special emphasis on the most recent studies in the field is given by discussing the results published by the main research groups who are working on NC and NCS. Chirality 28:169–180, 2016 . © 2016 Wiley Periodicals, Inc. Abstract :