Direct oral provocation tests in non‐immediate mild cutaneous reactions related to beta‐lactam antibiotics. Issue 1 (13th November 2015)

• Record Type: Journal Article
• Authors: Vezir, Emine; Dibek Misirlioglu, Emine; Civelek, Ersoy; Capanoglu, Murat; Guvenir, Hakan; Ginis, Tayfur; Toyran, Muge; Kocabas, Can N.
• Is Part Of: Pediatric allergy and immunology. Volume 27:Issue 1(2016)
• Page Start: 50
• Page End: 54
• Publication Date: 2015-11-13
• Subjects: beta‐lactam antibiotic -- children -- hypersensitivity -- non‐immediate reaction -- oral provocation test; Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.12493
• Languages: English
• ISSNs: 0905-6157

Abstract

Abstract : Background: Skin testing has a limited role in the diagnosis of non‐immediate beta‐lactam hypersensitivity in children. The aim of this study was to report the results of oral provocation tests performed without skin tests in children with non‐immediate mild cutaneous reactions without systemic symptoms caused by beta‐lactam antibiotics. Methods: Oral provocation tests with suspected antibiotics were performed to patients with non‐immediate mild cutaneous reactions without systemic symptoms caused by beta‐lactam antibiotics. Skin tests were not performed before provocation tests. A total of five doses were administered with half‐an‐hour intervals in increasing doses. Provocation was continued for 5 days. Results: A total of 119 patients with a median age of 4.3 (IQR: 2–7.5) years, of whom 58% were males, were included in the study. Amoxicillin–clavulanic acid was the most frequently responsible agent in 87 (73.1%) patients, and most common type of rash was maculopapular in 74 (62.2%) patients. Four patients (3.4%) had an urticarial reaction during the provocation test. Conclusion: We did not experience any severe reactions during oral provocation test without previous skin tests performed to children with non‐immediate mild cutaneous reactions without systemic symptoms. Omitting skin tests before oral provocation test in this group of children can help decreasing the burden of allergy clinics and alleviating the discomfort of children. Abstract :