Bilateral uveal melanomas with different gene expression detected with 7 years interval. (24th October 2015)

• Record Type: Journal Article
• Authors: Eide, Nils; Garred, Øystein; Beiske, Klaus; Fodstad, Øystein
• Is Part Of: Acta ophthalmologica. Volume 94:Number 1(2016)
• Page Start: 99
• Page End: 102
• Publication Date: 2015-10-24
• Subjects: bilateral uveal melanoma -- FISH monosomy‐BAP1 -- melanocytosis -- micrometastasis; Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1111/aos.12857
• Languages: English
• ISSNs: 1755-375X

Abstract

Abstract: Purpose: To report a bilateral uveal melanoma detected in a micrometastasis study. Method: Case report. Results: At enucleation of a circumpapillary amelanotic mixed melanoma in a patient with ocular melanocytosis, a pigmented lesion in the other eye was detected, thought to be a naevus. BAP1 was positive showing nuclear staining of the tumour cells. Seven years later the naevus showed growth and development of a retinal detachment. FNAB disclosed monosomy 3 in the spindle tumour cells. Conclusion: A case of bilateral melanoma with long‐term survival without metastatic diseases is reported. Different gene expressions in the two eyes were revealed. The case is a reminder that follow‐up over years is essential in patients with a uveal melanoma, especially with ocular melanocytosis.