Regioselective Copper‐Catalyzed Oxidative Cross‐Coupling of Imidazo[1, 2‐a]pyridines with Methyl Ketones: An Efficient Route for Synthesis of 1, 2‐Diketones. Issue 1 (17th December 2015)

• Record Type: Journal Article
• Authors: Lei, Sai; Chen, GuiJun; Mai, Yingying; Chen, Longbin; Cai, Huiyin; Tan, Jingwen; Cao, Hua
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 1(2016)
• Page Start: 67
• Page End: 73
• Publication Date: 2015-12-17
• Subjects: copper catalysts -- cross‐coupling -- 1, 2‐diketones -- imidazo[1, 2‐a]pyridines -- methyl ketones; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500803
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: An efficient copper‐catalyzed oxidative coupling of imidazo[1, 2‐ a ]pyridines with methyl ketones to directly generate structurally sophisticated 1, 2‐dicarbonyl imidazo[1, 2‐ a ]pyridine derivatives under oxidative conditions is described. The reaction proceeds in good yields using the environmental friendly molecular oxygen as the oxidant. 18 O‐Labelling experiments unambiguously established that the oxygen of the dicarbonyl products originated from oxygen rather than from water. Abstract :