Neocortical neuronal morphology in the newborn giraffe (Giraffa camelopardalis tippelskirchi) and African elephant (Loxodonta africana). Issue 2 (30th July 2015)

• Record Type: Journal Article
• Authors: Jacobs, Bob; Lee, Laura; Schall, Matthew; Raghanti, Mary Ann; Lewandowski, Albert H.; Kottwitz, Jack J.; Roberts, John F.; Hof, Patrick R.; Sherwood, Chet C.
• Is Part Of: Journal of comparative neurology. Volume 524:Issue 2(2016)
• Page Start: 257
• Page End: 287
• Publication Date: 2015-07-30
• Subjects: dendrite -- morphometry -- Golgi method -- brain evolution -- neocortex -- nif‐0000–10294; Comparative neurobiology -- Periodicals; Neurology -- Periodicals; 616
• DOI: 10.1002/cne.23841
• Languages: English
• ISSNs: 0021-9967

Abstract

ABSTRACT: Although neocortical neuronal morphology has been documented in the adult giraffe ( Giraffa camelopardalis tippelskirchi ) and African elephant ( Loxodonta africana ), no research has explored the cortical architecture in newborns of these species. To this end, the current study examined the morphology of neurons from several cortical areas in the newborn giraffe and elephant. After cortical neurons were stained with a modified Golgi technique (N = 153), dendritic branching and spine distributions were analyzed by using computer‐assisted morphometry. The results showed that newborn elephant neurons were considerably larger in terms of all dendritic and spine measures than newborn giraffe neurons. Qualitatively, neurons in the newborns appeared morphologically comparable to those in their adult counterparts. Neurons in the newborn elephant differed considerably from those observed in other placental mammals, including the giraffe, particularly with regard to the morphology of spiny projection neurons. Projection neurons were observed in both species, with a much larger variety in the elephant (e.g., flattened pyramidal, nonpyramidal multipolar, and inverted pyramidal neurons). Although local circuit neurons (i.e., interneurons, neurogliaform, Cajal–Retzius neurons) resembled those observed in other eutherian mammals, these were usually spiny, which contrasts with their adult, aspiny equivalents. Newborn projection neurons were smaller than the adult equivalents in both species, but newborn interneurons were approximately the same size as their adult counterparts. Cortical neuromorphology in the newborn giraffe is thus generally consistent with what has been observed in other cetartiodactyls, whereas newborn and adult elephant morphology appears to deviate substantially from what is commonly observed in other placental mammals. J. Comp. Neurol. 524:257–287, 2016. © 2015 Wiley Periodicals, Inc. Abstract : The current study examined the morphology of neocortical neurons in the newborn giraffe and elephant. The findings indicate that neurons in the giraffe cortex were similar to those of other cetartiodactyls, whereas neurons in elephant cortex varied greatly from those of other eutherian mammals.