Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease. Issue 1 (13th January 2016) - Chlebek, Jakub
Abstract: Two new isoquinoline alkaloids, named fumaranine (2 ) and fumarostrejdine (10 ), along with 18 known alkaloids were isolated from aerial parts of Fumaria officinalis. The structures of the isolated compounds were elucidated on the basis of spectroscopic analyses and by comparison with literature data. The absolute configuration of the new compound2 was determined by comparing its circular dichroism spectra with those of known analogs. Compounds isolated in sufficient amounts were evaluated for their acetylcholinesterase, butyrylcholinesterase, prolyl oligopeptidase (POP), and glycogen synthase kinase‐3 β inhibitory activities. Parfumidine (8 ) and sinactine (15 ) exhibited potent POP inhibition activities ( IC 50 99±5 and 53±2 μM, resp.). Abstract :