Marine Pyridoacridine Alkaloids: Biosynthesis and Biological Activities. Issue 1 (13th January 2016)

• Record Type: Journal Article
• Authors: Ibrahim, Sabrin R. M.; Mohamed, Gamal A.
• Is Part Of: Chemistry & biodiversity. Volume 13:Issue 1(2016:Jan.)
• Page Start: 37
• Page End: 47
• Publication Date: 2016-01-13
• Subjects: Alkaloids -- Pyridoacridine -- Ascidians -- Biosynthesis -- Biological activity; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.201400434
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Pyridoacridines are a class of strictly marine‐derived alkaloids that constitute one of the largest chemical families of marine alkaloids. During the last few years, both natural pyridoacridines and their analogues have constituted excellent targets for synthetic works. They have been the subject of intense study due to their significant biological activities; cytotoxic, antibacterial, antifungal, antiviral, insecticidal, anti‐HIV, and anti‐parasitic activities. In the present review, 95 pyridoacridine alkaloids isolated from marine organisms are discussed in term of their occurrence, biosynthesis, biological activities, and structural assignment. Abstract :