Ligand‐Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts. Issue 2 (27th November 2015)

• Record Type: Journal Article
• Authors: He, Jian; Jiang, Heng; Takise, Ryosuke; Zhu, Ru‐Yi; Chen, Gang; Dai, Hui‐Xiong; Dhar, T. G. Murali; Shi, Jun; Zhang, Hao; Cheng, Peter T. W.; Yu, Jin‐Quan
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 2(2016)
• Page Start: 785
• Page End: 789
• Publication Date: 2015-11-27
• Subjects: amino acids -- borylation -- CH activation -- palladium -- synthetic methods; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201509996
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A quinoline‐based ligand effectively promotes the palladium‐catalyzed borylation of C(sp 3 )H bonds. Primary β‐C(sp 3 )H bonds in carboxylic acid derivatives as well as secondary C(sp 3 )H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)‐ and rhodium(I)‐catalyzed CH borylation reactions in terms of scope and operational conditions. Abstract : A quinoline‐based ligand promotes the efficient palladium‐catalyzed borylation of primary β‐C(sp 3 )H bonds in carboxylic acid derivatives as well as secondary C(sp 3 )H bonds in a variety of carbocycles. This directed borylation method complements existing iridium(I)‐ and rhodium(I)‐catalyzed CH borylation reactions in terms of scope and reaction conditions.