Inside Cover: MiniAp‐4: A Venom‐Inspired Peptidomimetic for Brain Delivery (Angew. Chem. Int. Ed. 2/2016). Issue 2 (14th December 2015)

• Record Type: Journal Article
• Authors: Oller‐Salvia, Benjamí; Sánchez‐Navarro, Macarena; Ciudad, Sonia; Guiu, Marc; Arranz‐Gibert, Pol; Garcia, Cristina; Gomis, Roger R.; Cecchelli, Roméo; García, Jesús; Giralt, Ernest; Teixidó, Meritxell
• Is Part Of: Angewandte Chemie international edition. Volume 55:Issue 2(2016)
• Page Start: 454
• Page End: 454
• Publication Date: 2015-12-14
• Subjects: apamin -- blood–brain barrier -- drug delivery -- peptides; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201511247
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Drug delivery to the brain can be enhanced by using peptides that cross the blood–brain barrier. However, the efficacy of peptides is often limited by their protease lability. In their Communication onpage 572 ff., M. Teixidó, E. Giralt et al. develop a cyclic peptidomimetic (the key) derived from bee venom that efficiently transports cargoes into the brain parenchyma of mice and across human endothelial cells. This carrier is protease‐resistant and has negligible toxicity and immunogenicity.