Possible influence of AMPD1 on cholinergic neurotransmission and sleep. (6th October 2015)

• Record Type: Journal Article
• Authors: Buyse, Bertien; Van Damme, Philip; Belge, Catharina; Testelmans, Dries
• Is Part Of: Journal of sleep research. Volume 25:Number 1(2016:Mar.)
• Page Start: 124
• Page End: 126
• Publication Date: 2015-10-06
• Subjects: adenosine -- fatigue -- heart rate variability -- myalgia -- parasympathetic nervous system -- vagal tone; Sleep -- Periodicals; Sleep disorders -- Periodicals; 612.821
• DOI: 10.1111/jsr.12341
• Languages: English
• ISSNs: 0962-1105

Abstract

Summary: It is known that adenosine excess due to monophosphate deaminase deficiency (AMPD1) can be linked to muscle problems. Recently, Perumal et al ., 2014 reported a first case of possible impact of AMPD1 on sleep, REM sleep and cholinergic neurotransmission. We report a second patient with similar sleep complaints: long sleep duration with residual daytime sleepiness and a need to sleep after exercise. On polysomnography we observed a long sleep duration, with high sleep efficiency and a SOREMP; on MSLT a shortened sleep latency and 4 SOREMPS were observed. Frequency power spectral heart rate analysis during slow wave sleep, REM sleep and wakefulness revealed an increased parasympathetic tone. In conclusion, AMPD1 could have a profound influence on cholinergic neurotransmission and sleep; further studies are mandatory.