Cross‐species models of human melanoma. Issue 2 (9th October 2015)

• Record Type: Journal Article
• Authors: van der Weyden, Louise; Patton, E Elizabeth; Wood, Geoffrey A; Foote, Alastair K; Brenn, Thomas; Arends, Mark J; Adams, David J
• Is Part Of: Journal of pathology. Volume 238:Issue 2(2016)
• Page Start: 152
• Page End: 165
• Publication Date: 2015-10-09
• Subjects: melanoma -- cross‐species analysis -- genome analysis; Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.4632
• Languages: English
• ISSNs: 0022-3417

Abstract

Abstract : Although transformation of melanocytes to melanoma is rare, the rapid growth, systemic spread, as well as the chemoresistance of melanoma present significant challenges for patient care. Here we review animal models of melanoma, including murine, canine, equine, and zebrafish models, and detail the immense contribution these models have made to our knowledge of human melanoma development, and to melanocyte biology. We also highlight the opportunities for cross‐species comparative genomic studies of melanoma to identify the key molecular events that drive this complex disease. © 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.