Donor Hemodynamics as a Predictor of Outcomes After Kidney Transplantation From Donors After Cardiac Death. Issue 1 (11th September 2015)

• Record Type: Journal Article
• Authors: Allen, M. B.; Billig, E.; Reese, P. P.; Shults, J.; Hasz, R.; West, S.; Abt, P. L.
• Is Part Of: American journal of transplantation. Volume 16:Issue 1(2016:Jan.)
• Page Start: 181
• Page End: 193
• Publication Date: 2015-09-11
• Subjects: health services and outcomes research -- kidney transplantation / nephrology -- delayed graft function (DGF) -- donors and donation: donation after circulatory death (DCD) -- graft survival -- kidney (allograft) function /dysfunction -- risk assessment / risk stratification; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.13432
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : Donation after cardiac death is an important source of transplantable organs, but evidence suggests donor warm ischemia contributes to inferior outcomes. Attempts to predict recipient outcome using donor hemodynamic measurements have not yielded statistically significant results. We evaluated novel measures of donor hemodynamics as predictors of delayed graft function and graft failure in a cohort of 1050 kidneys from 566 donors. Hemodynamics were described using regression line slopes, areas under the curve, and time beyond thresholds for systolic blood pressure, oxygen saturation, and shock index (heart rate divided by systolic blood pressure). A logistic generalized estimation equation model showed that area under the curve for systolic blood pressure was predictive of delayed graft function (above median: odds ratio 1.42, 95% confidence interval [CI] 1.06–1.90). Multivariable Cox regression demonstrated that slope of oxygen saturation during the first 10 minutes after extubation was associated with graft failure (below median: hazard ratio 1.30, 95% CI 1.03–1.64), with 5‐year graft survival of 70.0% (95%CI 64.5%–74.8%) for donors above the median versus 61.4% (95%CI 55.5%–66.7%) for those below the median. Among older donors, increased shock index slope was associated with increased hazard of graft failure. Validation of these findings is necessary to determine the utility of characterizing donor warm ischemia to predict recipient outcome. Abstract : Using novel approaches to characterize donor hemodynamics in donation after cardiac death kidney transplantation, the authors show that data available at the time of organ procurement may predict delayed graft function and graft failure, particularly for recipients of kidneys from older donors.