Fiber probe for nonlinear imaging applications. Issue 1 (29th April 2015)

• Record Type: Journal Article
• Authors: Lukić, Aleksandar; Dochow, Sebastian; Chernavskaia, Olga; Latka, Ines; Matthäus, Christian; Schwuchow, Anka; Schmitt, Michael; Popp, Jürgen
• Is Part Of: Journal of biophotonics. Volume 9:Issue 1/2(2016)
• Page Start: 138
• Page End: 143
• Publication Date: 2015-04-29
• Subjects: diagnostic imaging -- fiber optic technology -- multimodal imaging -- microscopy; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201500010
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : Over the past years it had been demonstrated that multimodal imaging combining the nonlinear modalities coherent anti‐Stokes Raman scattering (CARS), two‐photon excited auto‐fluorescence (TPEF) and second harmonic generation (SHG) show a great potential for tissue diagnosis and tumor identification. To extend the applicability of this multimodal imaging approach for in‐vivo tissue screening of difficult to access body regions the development of suitable fiber optic probes is required. Here we report about a novel CARS imaging fiber probe consisting of 10, 000 coherent light guiding elements preserving the spatial relationship between the entrance and the output of the fiber. Therefore the scanning procedure can be shifted from the distal to the proximal end of the fiber probe and no moving parts or driving current are required to realize in‐vivo CARS endoscopy.Back scattered CARS image of rabbit aorta with plaques (white) using a laser scanning microscope and an imaging fiber. Abstract : Multimodal imaging combining the nonlinear modalities CARS, TPEF and SHG show a great potential for tissue diagnosis and tumor identification. A novel CARS imaging fiber probe is reported, consisting of 10, 000 coherent light guiding elements preserving the spatial relationship between the entrance and the output of the fiber. Therefore the scanning procedure can be shifted from the distal to the proximal end of the fiber probe and no moving parts or driving current are required to realize in‐vivo CARS endoscopy.