Prognostic value of level IV metastases from head and neck squamous cell carcinoma. Issue 1 (22nd May 2015)

• Record Type: Journal Article
• Authors: Hoch, Stephan; Katabi, Nour; Daniel, Hanna; Franke, Nora; Wiegand, Susanne; Zimmerman, Annette P.; Mandapathil, Magis; Ferlito, Alfio; Teymoortash, Afshin
• Is Part Of: Head & neck. Volume 38:Issue 1(2016)
• Page Start: 140
• Page End: 146
• Publication Date: 2015-05-22
• Subjects: level IV -- lymph node metastases -- head and neck cancer -- prognosis -- pulmonary metastases; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23861
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to evaluate the prognostic value of level IV metastases in head and neck squamous cell carcinoma (HNSCC). Methods: The clinical and histopathological data of 111 patients with HNSCC with pN+ neck who underwent a primary tumor resection with unilateral or bilateral neck dissection were analyzed. Results: Level IV metastases were histopathologically proven in 33 patients (29.7%). Pulmonary metastases were observed in 12 of 33 patients (36.4%) with level IV metastases, and in 13 of 78 patients (16.7%) without level IV metastases ( p = .04). Multivariate analyzes revealed a significant association between level IV metastases and pulmonary metastases ( p = .038). However, an influence on overall ( p = .65) or disease‐free survival ( p = .66) was not observed. Conclusion: Level IV metastases seem to be a predictive factor for pulmonary metastases but not for overall and disease‐free survival in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 140–146, 2016