Breast Cancer and Non‐Hodgkin Lymphoma in a Young Male with Cowden Syndrome. Issue 3 (15th October 2015)

• Record Type: Journal Article
• Authors: Hagelstrom, Robert Tanner; Ford, James; Reiser, Gwendolyn M.; Nelson, Marilu; Pickering, Diane L.; Althof, Pamela A.; Sanger, Warren G.; Coccia, Peter F.
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 3(2016)
• Page Start: 544
• Page End: 546
• Publication Date: 2015-10-15
• Subjects: Cowden syndrome -- B‐cell lymphoblastic lymphoma -- male breast cancer -- PTEN; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25796
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2 ); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [ PTEN ] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B‐cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.