Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests. Issue 3 (25th November 2015)

• Record Type: Journal Article
• Authors: Peters, Christian; Hoop, Marcus; Pané, Salvador; Nelson, Bradley J.; Hierold, Christofer
• Is Part Of: Advanced materials. Volume 28:Issue 3(2016)
• Page Start: 533
• Page End: 538
• Publication Date: 2015-11-25
• Subjects: cytotoxicity -- degradable composites -- superparamagnetic particles -- swimming microrobots -- targeted drug delivery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503112
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot platform mimicking Escherichia coli bacteria is fabricated and actuated using weak rotating magnetic fields. Locomotion based on corkscrew propulsion, targeted drug delivery, and low‐degradation‐product cytotoxicity are demonstrated.