Characterization and Effects of Ar/Air Microwave Plasma on Wound Healing. Issue 12 (30th April 2015)

• Record Type: Journal Article
• Authors: Kim, Ho Young; Kang, Sung Kil; Park, Seon Min; Jung, Hoe Yune; Choi, Bo Hwa; Sim, Jae Yoon; Lee, Jae Koo
• Is Part Of: Plasma processes and polymers. Volume 12:Issue 12 (2015)
• Page Start: 1423
• Page End: 1434
• Publication Date: 2015-04-30
• Subjects: air and gas temperature effect -- Ar/Air microwave atmospheric pressure plasma -- global model -- wound healing; Plasma polymerization -- Periodicals; Plasma-enhanced chemical vapor deposition -- Periodicals; Plasma chemistry -- Periodicals
• DOI: 10.1002/ppap.201500017
• Languages: English
• ISSNs: 1612-8850

Abstract

Abstract : Using Ar/Air mixture microwave plasma, we investigated the effects of air and gas temperature on the generation of electrons, ozone (O3 ), and nitric oxide (NO) through experiments and chemical kinetics simulation. The global model (GM) chemical kinetics simulation was used to validate and complement experimental observations. As the air percentages in Ar plasma increase, electrons are mainly generated by reactive oxygen species (ROS), but electron densities decrease. This is why plasma jet length becomes shorter with the mixture of air to Ar plasma at the same power. The profile of O3 densities has a maximum point because these are affected by oxygen (O2 ) molecules and gas temperature. O3 densities increase because these are generated via recombination of atomic oxygen (O) and O2 radicals as the air percentages increase. As the gas temperature increases, O3 densities decrease and O3 radicals are mainly destroyed by ROS such as O2 −, excited O2, and O, although air percentages increase. NO radicals increase continually with the addition of air mixture and increase in gas temperature. With respect to biomedical applications, in the case of Ar/Air plasma treatment, it takes just 2 d, which has reduced the wound area to 30% because of faster scab formation over the wound and mRNA activation. Abundant NO radicals with ROS in Ar/aAir plasma strongly enhance IL‐6 and TGF‐β1, which facilitate collagen remodeling and wound recovery effectively. Abstract : With Ar/Air microwave atmospheric pressure plasma, we investigate the effects of air and gas temperature on the generation of electrons, ozone (O3 ), and nitric oxide (NO). With this chemical kinetics simulation, the reasons for shorter plasma jet length, having a maximum area of O3 densities, and increasing NO radicals are analyzed. With wound healing experiments, in case of Ar/Air plasma treatment, it takes just 2 days, which has reduced the wound area to 30%.