Tissue Engineering: Electroconductive Nanopatterned Substrates for Enhanced Myogenic Differentiation and Maturation (Adv. Healthcare Mater. 1/2016). Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Yang, Hee Seok; Lee, Bora; Tsui, Jonathan H.; Macadangdang, Jesse; Jang, Seok‐Young; Im, Sung Gap; Kim, Deok‐Ho
• Is Part Of: Advanced healthcare materials. Volume 5:Issue 1(2016)
• Page Start: 1
• Page End: 1
• Publication Date: 2016-01
• Subjects: electroconductive substrates -- maturation -- myogenic differentiation -- nanotopography -- tissue engineering; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201670001
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Engineering mature and functional skeletal muscle tissue requires an ability to promote the structural organization and differentiation of cultured myoblasts. On page 137, D.‐H. Kim, S.G. Im, and co‐workers describe a bio‐inspired electroconductive culture platform, wherein a nanopatterned substrate mimicking the extracellular matrix of native muscle tissue is covered with a thin layer of gold. Engineered tissues using this platform feature hypertrophic and uniaxially aligned myotubes with increased expression levels of myogenic markers.