L‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles. Issue 3 (30th November 2015)

• Record Type: Journal Article
• Authors: McDonagh, Birgitte Hjelmeland; Singh, Gurvinder; Hak, Sjoerd; Bandyopadhyay, Sulalit; Augestad, Ingrid Lovise; Peddis, Davide; Sandvig, Ioanna; Sandvig, Axel; Glomm, Wilhelm Robert
• Is Part Of: Small. Volume 12:Issue 3(2016)
• Page Start: 301
• Page End: 306
• Publication Date: 2015-11-30
• Subjects: contrast agents -- l‐DOPA -- manganese -- manganese oxide -- MRI -- drug delivery; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201502545
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Manganese oxide nanoparticles (MONPs) are capable of time‐dependent magnetic resonance imaging contrast switching as well as releasing a surface‐bound drug. MONPs give T2/T2 * contrast, but dissolve and release T1‐active Mn 2+ andL ‐3, 4‐dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.