Melanoma arising in a nevus of Ito: novel genetic mutations and a review of the literature on cutaneous malignant transformation of dermal melanocytosis. (21st September 2015)

• Record Type: Journal Article
• Authors: Tse, Julie Y.; Walls, Brooke E.; Pomerantz, Hyemin; Yoon, Charles H.; Buchbinder, Elizabeth I.; Werchniak, Andrew E.; Dong, Fei; Lian, Christine G.; Granter, Scott R.
• Is Part Of: Journal of cutaneous pathology. Volume 43:Number 1(2016)
• Page Start: 57
• Page End: 63
• Publication Date: 2015-09-21
• Subjects: congenital nevus cells -- melanocytic lesions -- melanoma -- molecular pathology; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.12568
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Dermal melanocytosis refers to a spectrum of benign melanocytic proliferations that includes Mongolian spot, nevus of Ota and nevus of Ito. These lesions most commonly occur in persons of Asian or African descent and are often present at birth or develop during childhood. Very rarely, dermal melanocytoses undergo malignant transformation. There have been only 13 reports in the literature of primary cutaneous melanoma arising in dermal melanocytoses. We report a case of a Chinese woman with melanoma arising in a congenital nevus of Ito. We performed targeted next‐generation sequencing of the tumor which revealed mutations of GNAQ and BAP1, suggesting that alterations in these two genes led to malignant transformation of the nevus of Ito. We also provide a summary of reports in the literature regarding primary cutaneous melanoma arising in the context of dermal melanocytosis.