Diagnosis and management of aspergillosis in the Netherlands: a national survey. Issue 2 (9th December 2015)

• Record Type: Journal Article
• Authors: Lestrade, Pieter P. A.; Meis, Jacques F.; Arends, Jan P.; van der Beek, Martha T.; de Brauwer, Els; van Dijk, Karin; de Greeff, Sabine C.; Haas, Pieter‐Jan; Hodiamont, Caspar J.; Kuijper, Ed J.; Leenstra, Tjalling; Muller, Anouk E.; Oude Lashof, Astrid M. L.; Rijnders, Bart J.; Roelofsen, Eveline; Rozemeijer, Wouter; Tersmette, Mathijs; Terveer, Elizabeth M.; Verduin, Cees M.; Wolfhagen, Maurice J. H. M.; Melchers, Willem J. G.; Verweij, Paul E.
• Is Part Of: Mycoses. Volume 59:Issue 2(2016)
• Page Start: 101
• Page End: 107
• Publication Date: 2015-12-09
• Subjects: Aspergillosis -- azole resistance -- treatment; Pathogenic fungi -- Periodicals; Medical mycology -- Periodicals; 616.969
• DOI: 10.1111/myc.12440
• Languages: English
• ISSNs: 0933-7407

Abstract

Summary: A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non‐academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high‐risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.