Dispositions and tissue depletion of melamine in ducks. Issue 1 (24th May 2015)

• Record Type: Journal Article
• Authors: Suknikom, P.; Jermnak, U.; Poapolathep, S.; Isariyodom, S.; Giorgi, M.; Kumagai, S.; Poapolathep, A.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 39:Issue 1(2016)
• Page Start: 90
• Page End: 94
• Publication Date: 2015-05-24
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12242
• Languages: English
• ISSNs: 0140-7783

Abstract

Abstract : To evaluate the toxicokinetics and persistence of residues of melamine (MEL) in ducks, MEL was administered intravenously (i.v.) or orally (p.o.) to ducks at a dosage of 5.5 mg/kg body weight. The concentration of MEL in the plasma and various tissues was detected using HPLC equipped with an ultraviolet detector. The plasma concentration of MEL in ducks was determined up to 12 h after both i.v. and p.o. administrations. The average value of elimination half‐life ( t 1/2 β ) of MEL was 2.16 ± 0.37 and 2.01 ± 0.56 h after i.v. and p.o. administration, respectively. The absolute p.o. bioavailability was 90.79%. MEL was measurable in the liver and kidney after p.o. administration with maximum levels of 15.80 ± 1.81 and 15.49 ± 2.12 μg/g at 6 h, respectively. The results suggest that most of the administered MEL is efficiently absorbed from the gastro intestinal tract, and it has the ability to distribute into various tissues of the duck.