Oral candidiasis following steroid therapy for oral lichen planus. (13th January 2016)

• Record Type: Journal Article
• Authors: Marable, DR; Bowers, LM; Stout, TL; Stewart, CM; Berg, KM; Sankar, V; DeRossi, SS; Thoppay, JR; Brennan, MT
• Is Part Of: Oral diseases. Volume 22:Number 2(2016)
• Page Start: 140
• Page End: 147
• Publication Date: 2016-01-13
• Subjects: oral lichen planus -- oral candidiasis -- steroids; Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12399
• Languages: English
• ISSNs: 1354-523X

Abstract

Abstract : Objectives: The purpose of this multicentre study was to determine the incidence of oral candidiasis in patients treated with topical steroids for oral lichen planus (OLP) and to determine whether the application of a concurrent antifungal therapy prevented the development of an oral candidiasis in these patients. Materials and Methods: Records of 315 patients with OLP seen at four Oral Medicine practices treated for at least 2 weeks with steroids with and without the use of an antifungal regimen were retrospectively reviewed. Results: The overall incidence of oral fungal infection in those treated with steroid therapy for OLP was 13.6%. There was no statistically significant difference in the rate of oral candidiasis development in those treated with an antifungal regimen vs those not treated prophylactically (14.3% vs 12.6%) ( P = 0.68). Conclusions: Despite the use of various regimens, none of the preventive antifungal strategies used in this study resulted in a significant difference in the rate of development of an oral candidiasis in patients with OLP treated with steroids.