Efficacy and safety of salvage therapy using Carfilzomib for relapsed or refractory multiple myeloma patients: a multicentre retrospective observational study. (16th November 2015)

• Record Type: Journal Article
• Authors: Muchtar, Eli; Gatt, Moshe E.; Rouvio, Ory; Ganzel, Chezi; Chubar, Evgeni; Suriu, Celia; Tadmor, Tamar; Shevetz, Olga; Lavi, Noa; Shochat, Tzippy; Cohen, Yael C.; Avivi, Irit; Raanani, Pia; Magen, Hila
• Is Part Of: British journal of haematology. Volume 172:Number 1(2016)
• Page Start: 89
• Page End: 96
• Publication Date: 2015-11-16
• Subjects: carfilzomib -- myeloma -- relapse -- resistance; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.13799
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Carfilzomib has been established in previous years as a treatment for patients with relapsed and/or refractory multiple myeloma (RR‐MM). A retrospective multicentre study to evaluate the clinical use of carfilzomib for RR‐MM outside of a clinical trial setting was conducted by our group. One hundred and thirty‐five patients were included. All patients had been previously exposed to bortezomib and 93% had also been treated with lenalidomide. The vast majority of patients received carfilzomib as part of a two‐ or three‐drug combination. The overall response rate was 47·2%. Multivariate analysis revealed bortezomib resistance, lenalidomide resistance and albumin <35 g/l to negatively impact the likelihood of achieving response. The median duration of response was 8·4 months, and was significantly higher in patients receiving three‐drug combination and patients presenting without extramedullary disease. The median progression‐free survival and overall survival for the entire cohort was 4·9 months (95% confidence interval [CI] 3·8–6·4) and 12·2 months (95% CI 9‐not reached), respectively. Toxicity was manageable, although treatment‐related death was seen in 5% of patients. In the setting of progressive multiple myeloma, carfilzomib in a combination regimens yields effective results with a manageable toxicity.