BCOR internal tandem duplication and YWHAE–NUTM2B/E fusion are mutually exclusive events in clear cell sarcoma of the kidney. Issue 2 (23rd October 2015)

• Record Type: Journal Article
• Authors: Karlsson, Jenny; Valind, Anders; Gisselsson, David
• Is Part Of: Genes, chromosomes & cancer. Volume 55:Issue 2(2016:Feb.)
• Page Start: 120
• Page End: 123
• Publication Date: 2015-10-23
• Subjects: Cancer -- Genetic aspects -- Periodicals; 616.994042
• DOI: 10.1002/gcc.22316
• Languages: English
• ISSNs: 1045-2257

Abstract

Abstract : Clear cell sarcoma of the kidney (CCSK) is the second most common pediatric renal tumor. Two recurrent genetic aberrations have been described in CCSK. One is a fusion of YWHAE and NUTM2B/E, the other is an internal tandem duplication (ITD) in the BCOR gene. Here it is shown that YWHAE – NUTM2B/E fusion and the BCOR ITD are mutually exclusive events and activated different downstream signaling systems. This has important diagnostic implications and opens up for further mechanistic studies of CCSK pathogenesis. © 2015 Wiley Periodicals, Inc.