Imatinib Treatment in PDGFRA‐Negative Childhood Hypereosinophilic Syndrome. Issue 1 (8th August 2015)

• Record Type: Journal Article
• Authors: Weyand, Angela C.; Yanik, Gregory A.; Bailey, Nathanael G.; Wu, Yi‐Mi; Mody, Rajen J.; Castle, Valerie P.
• Is Part Of: Pediatric blood & cancer. Volume 63:Issue 1(2016)
• Page Start: 164
• Page End: 167
• Publication Date: 2015-08-08
• Subjects: hypereosinophilia -- imatinib -- PDGFRA -- pediatric; Tumors in children -- Periodicals; Blood -- Diseases -- Periodicals; Cancer in children -- Periodicals; 618.92
• DOI: 10.1002/pbc.25702
• Languages: English
• ISSNs: 1545-5009

Abstract

Abstract : We report a 4‐year‐old female who presented with severe hypereosinophilia (215.7 K/μl) and end‐organ dysfunction. Extensive evaluation including whole exome sequencing was performed, revealing no causative mutation. Initial treatment with corticosteroids, leukapheresis, and hydroxyurea decreased her absolute eosinophil count (AEC), although it remained elevated. Despite the absence of a PDGFRA mutation, an imatinib trial resulted in normalization of her AEC. Imatinib was discontinued after sustained normal counts for 1 month. AECs have remained normal for more than 1 year off therapy. This provides support for consideration of imatinib in the treatment of hypereosinophilia even in the absence of a known tyrosine kinase mutation. Pediatr Blood Cancer 2015; 9999:XX–XX © 2015 Wiley Periodicals, Inc.