The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents. Issue 4 (28th April 2015)

• Record Type: Journal Article
• Authors: Saunier, Elise; Benelli, Chantal; Bortoli, Sylvie
• Is Part Of: International journal of cancer. Volume 138:Issue 4(2016:Feb. 15)
• Page Start: 809
• Page End: 817
• Publication Date: 2015-04-28
• Subjects: pyruvate dehydrogenase complex -- pyruvate dehydrogenase kinase -- pyruvate dehydrogenase phosphatase -- Warburg effect -- cancer metabolism -- PDK inhibitors; Cancer -- Periodicals; Cancer -- Prevention -- Periodicals; 616.994
• DOI: 10.1002/ijc.29564
• Languages: English
• ISSNs: 0020-7136

Abstract

Abstract : Cancer cells exhibit an altered metabolism which is characterized by a preference for aerobic glycolysis more than mitochondrial oxidation of pyruvate. This provides anabolic support and selective growth advantage for cancer cells. Recently, a new concept has arisen suggesting that these metabolic changes may be due, in part, to an attenuated mitochondrial function which results from the inhibition of the pyruvate dehydrogenase complex (PDC). This mitochondrial complex links glycolysis to the Krebs cycle and the current understanding of its regulation involves the cyclic phosphorylation and dephosphorylation by specific pyruvate dehydrogenase kinases (PDKs) and pyruvate dehydrogenase phosphatases (PDPs).