Prevalence of fragrance contact allergy in the general population of five European countries: a cross‐sectional study. (7th November 2015) - Diepgen, T.L.
Summary: Background: Contact allergy to fragrances is assessed mostly in clinical populations of patients. Studies in the general population are scarce and vary in their methodology across countries. Objectives: To determine the prevalence of fragrance contact allergy in the European general population and to assess the clinical relevance of positive patch test reactions to different fragrances. Methods: In five European countries (Germany, Italy, the Netherlands, Portugal and Sweden) a random sample from the general population aged 18–74 years was drawn. In total, 12 377 subjects were interviewed in this cross‐sectional study and a random sample ( n = 3119) was patch tested using the TRUE Test and Finn Chamber techniques. Patch test procedures were harmonized by mandatory training before the study and monitoring during the study. Results: The highest prevalence for contact allergy of 2·6% [95% confidence interval (CI) 2·1–3·2] was found for fragrance mix (FM) I in petrolatum, with a high content of atranol and chloratranol, followed by 1·9% (95% CI 1·5–2·4) for FM II in petrolatum. The conservatively estimated prevalence of fragrance contact allergy was 1·9% (95% CI 1·5–2·5). This is defined as the existence of a positive patch test to FM I or FM II; any of their individual materials; Myroxylon pereirae ; sesquiterpene lactones or 3‐ and 4‐hydroxyisohexyl 3‐cyclohexene carboxaldehyde that show clinical relevance, defined conservatively as lifetime avoidance of scented products and an itchy skin rash lasting > 3 days in a lifetime. Using the reported lifetime prevalence of any contact dermatitis instead of the lifetime prevalence of any itchy skin rash, the prevalence is 0·8% (95% CI 0·5–1·2). The prevalence rates of contact allergy to fragrances in women are about twice those in men. Conclusions: This study helps to identify targets for prevention of fragrance allergy. Abstract : What's already known about this topic? Contact allergy to fragrances is very common, and a prevalence rate of up to 14% has been reported in studies of clinical populations. Studies in the general population are scarce and vary in their methodology across countries. What does this study add? We report the prevalence of contact allergy to fragrance mix (FM) I and FM II and avoidance of scented products in five European countries. High avoidance rates of scented products due to skin complaints were reported for leave‐on, rinse‐off, and household or functional products. The highest prevalence for contact allergy (2·6%) was found for FM I in petrolatum, followed by 1·9% for FM II in petrolatum, with a higher prevalence in women. There was no statistically significant difference for contact allergy to the different fragrance allergens between countries. Linked Comment: Uter, Br J Dermatol 2015; 173: 1358–59 .