Chronic invasive fungal sinusitis associated with intranasal drug use. (7th July 2015)

• Record Type: Journal Article
• Authors: Pekala, Kelly R.; Clavenna, Matthew J.; Shockley, Ross; Weiss, Vivian L.; Turner, Justin H.
• Is Part Of: Laryngoscope. Volume 125:Number 12(2015:Dec.)
• Page Start: 2656
• Page End: 2659
• Publication Date: 2015-07-07
• Subjects: Invasive fungal sinusitis -- chronic granulomatous -- invasive -- Aspergillus -- Mucor -- cocaine -- intranasal drug -- sinusitis -- perforation; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.25429
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Chronic invasive fungal sinusitis (CIFS) is a rare but potentially aggressive form of invasive fungal disease that occurs in immunocompetent patients. We report a case of CIFS in an otherwise healthy young adult associated with intranasal illicit drug abuse. The patient presented with nonhealing nasal septal and palatal perforations. Biopsy demonstrated invasive Aspergillus flavus requiring surgical debridement and extended intravenous antifungal therapy. Tissue necrosis and ulceration related to intranasal drug use should be recognized as a potential risk factor for invasive fungal sinusitis. Laryngoscope, 125:2656–2659, 2015