Acceleration of Bone Regeneration by BMP‐2‐Loaded Collagenated Biphasic Calcium Phosphate in Rabbit Sinus. (28th March 2014)

• Record Type: Journal Article
• Authors: Kim, Jung‐Soo; Cha, Jae‐Kook; Cho, Ah‐Ran; Kim, Min‐Soo; Lee, Jung‐Seok; Hong, Ji‐Youn; Choi, Seong‐Ho; Jung, Ui‐Won
• Is Part Of: Clinical implant dentistry and related research. Volume 17:Number 6(2015:Dec.)
• Page Start: 1103
• Page End: 1113
• Publication Date: 2014-03-28
• Subjects: bone regeneration -- bone substitutes -- bone tissue engineering -- sinus augmentation; Dental implants -- Periodicals; Dental Implantation -- Periodicals; Dental Implants -- Periodicals; 617.693
• DOI: 10.1111/cid.12223
• Languages: English
• ISSNs: 1523-0899

Abstract

Abstract: Purpose: The objective of this study was to determine the effectiveness of collagenated biphasic calcium phosphate (CBCP) as a carrier for bone morphogenetic protein‐2 (BMP‐2) at the early stage of healing in rabbit sinus. Material and Methods: In 16 rabbits, BMP‐2‐loaded CBCP was grafted into one sinus (the BMP group) and saline‐soaked CBCP was grafted into another sinus (the CTL group). The groups were assigned randomly. After 2 weeks ( n = 8) or 4 weeks ( n = 8), radiographic and histological analysis was performed. Results: Total augmented volume was significantly larger in the BMP group at both healing periods. Furthermore, new bone volume was significantly greater in the BMP group at 4 weeks. Marked bone formation near the schneiderian membrane was found in the BMP groups at the early healing period. At 4 weeks, evenly distributed new bone was observed in the BMP group, whereas the new bone was sparsely distributed in the central portion in the CTL group. Conclusion: It can be concluded that the addition of BMP‐2 to CBCP resulted in a greater initial augmented volume as a result of postoperative swelling, which is replaced by early bone formation, and it was prominent near the Schneiderian membrane.