Near‐Infrared Spatially Resolved Spectroscopy for Tablet Quality Determination. Issue 12 (28th August 2015)

• Record Type: Journal Article
• Authors: Igne, Benoît; Talwar, Sameer; Feng, Hanzhou; Drennen, James K.; Anderson, Carl A.
• Is Part Of: Journal of pharmaceutical sciences. Volume 104:Issue 12(2015:Dec.)
• Page Start: 4074
• Page End: 4081
• Publication Date: 2015-08-28
• Subjects: near‐infrared spectroscopy -- partial least squares -- multivariate analysis -- chemometrics -- content uniformity -- diffuse reflectance -- tableting -- spatially resolved spectroscopy; Pharmacy -- Periodicals; 615.1
• DOI: 10.1002/jps.24618
• Languages: English
• ISSNs: 0022-3549

Abstract

Abstract : Near‐infrared (NIR) spectroscopy has become a well‐established tool for the characterization of solid oral dosage forms manufacturing processes and finished products. In this work, the utility of a traditional single‐point NIR measurement was compared with that of a spatially resolved spectroscopic (SRS) measurement for the determination of tablet assay. Experimental designs were used to create samples that allowed for calibration models to be developed and tested on both instruments. Samples possessing a poor distribution of ingredients (highly heterogeneous) were prepared by under‐blending constituents prior to compaction to compare the analytical capabilities of the two NIR methods. The results indicate that SRS can provide spatial information that is usually obtainable only through imaging experiments for the determination of local heterogeneity and detection of abnormal tablets that would not be detected with single‐point spectroscopy, thus complementing traditional NIR measurement systems for in‐line, and in real‐time tablet analysis. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:4074–4081, 2015