Bioaccumulation of decamethylpentacyclosiloxane (D5): A review. (30th October 2015) - Gobas, Frank A.P.C.
Abstract: Decamethylpentacyclosiloxane (D5) is a widely used, high–production volume personal care product with an octanol–water partition coefficient (log K OW ) of 8.09. Because of D5's high K OW and widespread use, it is subject to bioaccumulation assessments in many countries. The present study provides a compilation and an in‐depth, independent review of bioaccumulation studies involving D5. The findings indicate that D5 exhibits depuration rates in fish and mammals that exceed those of extremely hydrophobic, nonbiotransformable substances; that D5 is subject to biotransformation in mammals and fish; that observed bioconcentration factors in fish range between 1040 L/kg and 4920 L/kg wet weight in laboratory studies using non‐radiolabeled D5 and between 5900 L/kg and 13 700 L/kg wet weight in an experiment using C 14 radiolabeled D5; and that D5 was not observed to biomagnify in most laboratory experiments and field studies. Review of the available studies shows a high degree of internal consistency among findings from different studies and supports a broad comprehensive approach in bioaccumulation assessments that includes information from studies with a variety of designs and incorporates multiple bioaccumulation measures in addition to the K OW and bioconcentration factor. Environ Toxicol Chem 2015;34:2703–2714. © 2015 The Authors. Environmental Toxicology and Chemistry Published by Wiley Periodicals, Inc. on behalf of SETAC.