B‐1 phagocytes: the myeloid face of B‐1 cells. Issue 1 (6th July 2015)

• Record Type: Journal Article
• Authors: Popi, Ana Flavia
• Is Part Of: Annals of the New York Academy of Sciences. Volume 1362:Issue 1(2015)
• Page Start: 86
• Page End: 97
• Publication Date: 2015-07-06
• Subjects: B‐1 cells -- myeloid -- lymphoid -- phagocytosis; Medical sciences -- Periodicals; Medicine -- Periodicals; Science -- Periodicals; 610
• DOI: 10.1111/nyas.12814
• Languages: English
• ISSNs: 0077-8923

Abstract

Abstract : The relationship between malignant B cells and macrophages has long been established. Furthermore, evolutionary studies have demonstrated that B cells from early vertebrates have both phagocytic and antibody production capabilities. In addition to their lymphoid nature, B‐1 cells retain several myeloid characteristics. Various reports have demonstrated that B‐1 cells can differentiate into phagocytes. However, descriptions of B‐1 cells as a novel phagocyte cell member are rarely found in the literature. This review aims to present the available data regarding B‐1 cell–derived phagocytes and also discusses how their existence might be relevant to hematopoiesis and immune responses.