Bioimaging: Are Fluorescent Organic Nanoparticles Relevant Tools for Tracking Cancer Cells or Macrophages? (Adv. Healthcare Mater. 17/2015). Issue 17 (December 2015)

• Record Type: Journal Article
• Authors: Faucon, Adrien; Benhelli‐Mokrani, Houda; Córdova, Luis A.; Brulin, Bénédicte; Heymann, Dominique; Hulin, Philippe; Nedellec, Steven; Ishow, Eléna
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 17(2015)
• Page Start: 2600
• Page End: 2600
• Publication Date: 2015-12
• Subjects: biodegradation -- bioimaging -- cancer cells -- fluorescent organic nanoparticles -- monocytes/macrophages; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201570097
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Fluorescent organic nanoparticles (FONs), made of self‐assembled solvatochromic fluorophores, represent a novel class of bright imaging agents. On page 2727, E. Ishow and co‐workers show how in cellulo studies evidence dramatic dissembling of FONs by macrophages compared to cancer cells. Macrophages disintegrate internalized yellow‐emitting FONs and expulse the individual components by excreting vesicles. Strong green fluorescence arises from the solvatochromic fluorophores dissolved in the rich lipid content of vesicles (Cover design: Nicolas Gazut).