Role of Shape in Tumor Environment: Cubical Shape Enhances the Interaction of Layer‐by‐Layer Polymeric Particles with Breast Cancer Cells (Adv. Healthcare Mater. 17/2015). Issue 17 (December 2015)

• Record Type: Journal Article
• Authors: Alexander, Jenolyn F.; Kozlovskaya, Veronika; Chen, Jun; Kuncewicz, Thomas; Kharlampieva, Eugenia; Godin, Biana
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 17(2015)
• Page Start: 2599
• Page End: 2599
• Publication Date: 2015-12
• Subjects: elasticity -- multilayer capsules -- particles -- shape -- tumor microenvironment; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201570096
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : Understanding the role of shape and elasticity in the behavior of objects in the tumor microenvironment is crucial for designing more efficient and less toxic therapies. On page 2657, E. Kharlampieva, B. Godin, and co‐workers explore spherical and cubic biocompatible elastic microshells and their rigid core–shell precursors. The cover image, which is a superimposition of confocal (cells and particles) and scanning electron (particles) micrographs, illustrates how the cubic shape promotes the interaction of particles with breast cancer cells.