Incidence and risk factors for myelofibrotic transformation among 272 Chinese patients with JAK2‐mutated polycythemia vera. Issue 12 (17th November 2015)

• Record Type: Journal Article
• Authors: Bai, Jie; Ai, Limei; Zhang, Lei; Yang, Feng‐Chun; Zhou, Yuan; Xue, Yanping
• Is Part Of: American journal of hematology. Volume 90:Issue 12(2015:Dec.)
• Page Start: 1116
• Page End: 1121
• Publication Date: 2015-11-17
• Subjects: Hematology -- Periodicals; 616.15
• DOI: 10.1002/ajh.24191
• Languages: English
• ISSNs: 0361-8609

Abstract

Abstract : Post‐polycythemia vera myelofibrosis (post‐PV MF) is a critical hematologic evolution of polycythemia vera (PV). The main purpose of the present study was to identify the possible risk factors for the occurrence and prognosis of post‐PV MF in Chinese patients with PV. A cohort of 272 Chinese PV patients with JAK2 V617F or exon12 mutation was retrospectively analyzed. Of the 272 patients with PV, 63 developed post‐PV MF. Platelet count >550 × 10 9 /L and splenomegaly were identified as independent risk factors for post‐PV MF. The median duration of survival for post‐PV MF patients was 8 years. Anemia and age >65 years at diagnosis of post‐PV MF were identified as significant predictors for the poor prognosis of post‐PV MF. In conclusion, platelet counts and splenomegaly were significant predictors for the transformation to post‐PV MF, while anemia (hemoglobin levels <100 g/L) and age>65 years were significant predictors for poor prognosis of post‐PV MF in Chinese PV patients with JAK2 V617F or exon12 mutation. Am. J. Hematol. 90:1116–1121, 2015. © 2015 Wiley Periodicals, Inc.