Vitamin D Status in Different Stages of Disease Severity in Dogs with Chronic Valvular Heart Disease. (30th August 2015)

• Record Type: Journal Article
• Authors: Osuga, T.; Nakamura, K.; Morita, T.; Lim, S.Y.; Nisa, K.; Yokoyama, N.; Sasaki, N.; Morishita, K.; Ohta, H.; Takiguchi, M.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 6(2015:Nov./Dec.)
• Page Start: 1518
• Page End: 1523
• Publication Date: 2015-08-30
• Subjects: 25‐Hydroxyvitamin D -- Cardiac remodeling -- Dog -- Echocardiography; Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.13606
• Languages: English
• ISSNs: 0891-6640

Abstract

Abstract : Background: In humans with heart disease, vitamin D deficiency is associated with disease progression and a poor prognosis. A recent study showed that serum 25‐hydroxyvitamin D [25(OH)D] concentration, the hallmark of vitamin D status, was lower in dogs with heart failure than in normal dogs, and a low concentration was associated with poor outcome in dogs with heart failure. Objectives: To elucidate the vitamin D status of dogs with chronic valvular heart disease (CVHD) at different stages of disease severity. Animals: Forty‐three client‐owned dogs with CVHD. Methods: In this cross‐sectional study, dogs were divided into 3 groups (14 dogs in Stage B1, 17 dogs in Stage B2, and 12 dogs in Stage C/D) according to ACVIM guidelines. Dogs underwent clinical examination including echocardiography. Serum 25(OH)D concentrations were measured in each dog. Results: Serum 25(OH)D concentration was significantly lower in Stage B2 (median, 33.2 nmol/L; range, 4.9–171.7 nmol/L) and C/D (13.1 nmol/L; 4.9–58.1 nmol/L) than in Stage B1 (52.5 nmol/L; 33.5–178.0 nmol/L) and was not significantly different between Stage B2 and Stage C/D. Among clinical variables, there were significant negative correlations between 25(OH)D concentration and both left atrial‐to‐aortic root ratio and left ventricular end‐diastolic diameter normalized for body weight. Conclusions and Clinical Importance: These results indicate that vitamin D status is associated with the degree of cardiac remodeling, and the serum 25(OH)D concentration begins to decrease before the onset of heart failure in dogs with CVHD.