Cover Picture: Synthesis of Osthole Derivatives with Grignard Reagents and Their Larvicidal Activities on Mosquitoes (Chin. J. Chem. 12/2015). Issue 12 (December 2015)

• Record Type: Journal Article
• Authors: Liu, Ming; Liu, Yang; Hua, Xuewen; Wu, Changchun; Zhou, Sha; Wang, Baolei; Li, Zhengming
• Is Part Of: Chinese journal of chemistry. Volume 33:Issue 12(2015:Dec.)
• Page Start: 1325
• Page End: 1325
• Publication Date: 2015-12
• Subjects: osthole derivatives -- mosquito larvicide -- Grignard reagents -- synthesis -- promoter; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201590027
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract : The cover picture shows an inexpensive and eco‐friendly method to synthesize osthole derivatives with Grignard reagents assisted by CuI and LiCl. With the purpose of discovering novel insecticides from Traditional Chinese Medicine (TCM), the structure of osthole has been modified to improve its larvicidal activity against mosquitoes. Starting from Grignard reagents generated from 8‐iodocoumarins, a broad range of osthole derivatives can be prepared in mild to good yields (up to 83%). Bio‐activity evaluation showed that several products exhibited better larvicidal activities than osthole. More details are discussed in the article by Li et al . on page 1353–1358.