Asymmetric Hydrophosphonylation of Aldehydes using a Cinchona–Diaminomethylenemalononitrile Organocatalyst. Issue 18 (9th December 2015)

• Record Type: Journal Article
• Authors: Hirashima, Shin‐ichi; Arai, Ryoga; Nakashima, Kosuke; Kawai, Nobuaki; Kondo, Junko; Koseki, Yuji; Miura, Tsuyoshi
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 18(2015)
• Page Start: 3863
• Page End: 3867
• Publication Date: 2015-12-09
• Subjects: asymmetric reactions -- diaminomethylenemalononitrile -- hydrophosphonylation -- organocatalysts -- Pudovik reaction; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500816
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: For the asymmetric hydrophosphonylation of aldehydes, an efficient organocatalytic approach with a diaminomethylenemalononitrile‐based hydrogen‐bonding donor catalyst is presented. The catalyst induces high yields and excellent enantioselectivities (up to 98% yield, 96% ee ). Abstract :