Rhodium(III)‐Catalyzed Synthesis of Aryl Spirocycles by Aromatic CH Activation/Intramolecular Heck‐Type Reaction. Issue 18 (25th November 2015)

• Record Type: Journal Article
• Authors: Chabaud, Laurent; Raynal, Quentin; Barre, Elvina; Guillou, Catherine
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 18(2015)
• Page Start: 3880
• Page End: 3884
• Publication Date: 2015-11-25
• Subjects: catalysis -- CH activation -- Heck‐type reaction -- rhodium -- spiro compounds; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500768
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: The rhodium(III)‐catalyzed aromatic CH activation/intramolecular Heck‐type reaction has been studied to synthesize spirocyclic compounds, an important class of molecules in medicinal chemistry and natural product synthesis. This approach was efficient with a variety of substituted N ‐methoxybenzamides tethered to different cyclic alkenes having a 5‐, 6‐ or 7‐membered ring. This practical method affords sterically hindered o ‐substituted aryl spirocycles that are valuable compounds for further functionalization to access relevant building blocks. Abstract :